Publications
Selected peer-reviewed research
A selection of recent work from the lab across stem cell expansion, chemogenomics, and the Leucegene project.
Full publication record
Browse the complete, continuously updated list of Dr. Sauvageau's publications on ORCID.
- ViewAML2026
TP53-mutant AML with ribosomal gene loss exhibits impaired protein translation and sensitivity to HSP90 inhibition.
Spinella JF, Chagraoui J, Moison C, … Hébert J, Sauvageau G.
Science Advances
- ViewAML2026
CD33 epitope editing unlocks UM171-expanded cord blood grafts for AML immunotherapy.
Lehnertz B, Langouët M, Corneau S, … Gagnon E, Macauley MS, Sauvageau G.
Molecular Therapy
- ViewAML2025
CoREST in pieces: Dismantling the CoREST complex for cancer therapy and beyond.
Ismail H, Chagraoui J, Sauvageau G.
Science Advances
- ViewAML2025
DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition.
Moison C, Mendoza-Sanchez R, Gracias D, … Marinier A, Sauvageau G.
EMBO Reports
- ViewHSC2025
Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis.
Coulombe P, Tomellini E, Chagraoui J, Mayotte N, Sauvageau G.
Nature Communications
- ViewAML2024
Immunotherapeutic targeting of surfaceome heterogeneity in AML.
Bordeleau ME, Audemard E, Metois A, … Roux PP, Sauvageau G.
Cell Reports
- ViewAML2024
SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia.
Moison C, Gracias D, Schmitt J, … Marinier A, Sauvageau G.
Science Advances
- ViewAML2024
DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML.
Spinella JF, Chagraoui J, Moison C, … Hébert J, Sauvageau G.
Leukemia
- ViewHSC2023
KBTBD4-mediated reduction of MYC is critical for hematopoietic stem cell expansion upon UM171 treatment.
Chagraoui J, Girard S, Mallinger L, Mayotte N, Tellechea MF, Sauvageau G.
Blood
- ViewHSC2023
Improved outcomes of UM171-expanded cord blood transplantation compared with other graft sources.
Cohen S, Bambace N, Ahmad I, … Veilleux O, Sauvageau G.
Blood Advances
- ViewHSC2021
HLF expression defines the human hematopoietic stem cell state.
Lehnertz B, Chagraoui J, MacRae T, … Gracias D, Sauvageau G.
Blood
- ViewHSC2021
UM171 preserves epigenetic marks that are reduced in ex vivo culture of human HSCs via potentiation of the CLR3-KBTBD4 complex.
Chagraoui J, Girard S, Spinella JF, … Marinier A, Sauvageau G.
Cell Stem Cell
- ViewHSC2019
Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a phase 1-2 study.
Cohen S, Roy J, Lachance S, … Zandstra PW, Sauvageau G.
Lancet Haematology
- ViewAML2019
Mubritinib targets the electron transport chain complex I and reveals OXPHOS dependency in AML.
Baccelli I, Gareau Y, Lehnertz B, … Marinier A, Sauvageau G.
Cancer Cell
- ViewAML2015
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.
Lavallée VP, Baccelli I, Krosl J, … Hébert J, Sauvageau G.
Nature Genetics
- ViewHSC2014
Cord blood expansion: pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.
Fares I, Chagraoui J, Gareau Y, … Zandstra PW, Sauvageau G.
Science
- ViewAML2014
Identification of small molecules that support human leukemia stem cell activity ex vivo.
Pabst C, Krosl J, Fares I, … Hébert J, Sauvageau G.
Nature Methods
- ViewHSC2003
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard J, Sauvageau G.
Nature
- ViewHSC2002
HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.
Antonchuk J, Sauvageau G, Humphries RK.
Cell