Selected Publications


LavalléVP, Gendron P, Lemieux S, D'Angelo G, Hért J, Sauvageau G. (2014). EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations. Blood. DOI: 10.1182/blood-2014-07-591529

Fares, I., Chagraoui, J., Gareau, Y., Gingras, S., Ruel, R., Mayotte, N., Csaszar, E., Knapp, D.J.H.F., Miller, P., Ngom, M., Imren S, Roy DC, Watts K.L, Kiem HP, Herrington R, Iscove N, Humphries K, Eaves C, Cohen S, Marinier A, Zandstra PW, Sauvageau G. (2014) Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science 345, 1509.1512.

Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé, Hért J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G. (2014) UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Blood. DOI: 10.1182/blood-2014-01-548651

Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G. (2014) Identification of small molecules that support human leukemia stem cell activity ex vivo. Nature Methods, doi:10.1038/nmeth.2847


Macrae T, Sargeant T, Lemieux S, Hébert J, Deneault E, Sauvageau G. (2013) RNA-Seq Reveals Spliceosome and Proteasome Genes as Most Consistent Transcripts in Human Cancer Cells. PLoS ONE 2013-01-01;8(9):e72884.

Cellot S, Hope KJ, Chagraoui J, Sauvageau M, Deneault E, Macrae T, Mayotte N, Wilhelm BT, Landry JR, Ting SB, Krosl J, Humphries K, Thompson A, Sauvageau G. (2013). RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity. Blood. doi: 10.1182/blood-2013-04-496281

Deneault E, Wilhelm BT, Bergeron A, Barabé F and Sauvageau G. (2013). Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity. Exp Hematol. Jan 19. [Epub ahead of print]


Simon C, Chagraoui J, Krosl J and Sauvageau G. (2012). A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes Dev. 26, 651-656.


Ting SB, Deneault E, Hope K, Cellot S, Chagraoui J, Mayotte N, Dorn JF, Laverdure JP, Harvey M, Hawkins ED, Russell SM, Maddox PS, Iscove NN, Sauvageau G.(2011). Asymmetrical segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2. Blood 119,2510-2522.

Bisaillon R, Wilhelm BT, Krosl J and Sauvageau G. (2011). C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein. Blood 118, 4682-4689.

Chagraoui J, Hebert J, Girard S and Sauvageau G. (2011). An anticlastogenic function for the Polycomb Group gene Bmi1. PNAS 108(13):5284-9.

Wilhelm BT, Briau M, Austin P, Faubert A, Boucher G, Chagnon P, Hope K, Girard S, Mayotte N, Landry JR, Hebert J and Sauvageau G. (2011). RNA-seq Analysis of Two Closely Related Leukemia clones that Differ in their Self-Renewal Capacity. Blood 117,27-38.


Fortier S, Bilodeau M, MacRae T, Laverdure JP, Azcoitia V, Girard S, Chagraoui J, Ringuette N, Hébert J, Krosl J, Mayotte N and Sauvageau G. (2010). Genome-Wide Interrogation of Mammalian Stem Cell Fate Determinants by Nested Chromosome Deletions. PLoS Genetics 6(12): e1001241.

Sauvageau M and Sauvageau G. (2010). Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer. Cell Stem Cell 7, 299-313.

Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN and Sauvageau G. (2010). An RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity. Cell Stem Cell 7, 101-113.

Krosl J, Mamo A, Chagraoui J, Wilhelm BT, Girard S, Louis I, Lessard J, Perreault C and Sauvageau G. (2010). A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell population. Blood 116, 1678-1684.


Deneault E, Cellot S, Faubert A, Laverdure JP, Frechette M, Chagraoui J, Mayotte N, Sauvageau M, Ting SB, and Sauvageau G. (2009). A Functional Screen to Identify Novel Effectors of Hematopoietic Stem Cell Activity. Cell, 137, 369-379.

Bilodeau M, MacRae T, Gaboury L, Laverdure JP, Hardy MP, Mayotte N, Paradis V, Harton S, Perreault C and Sauvageau G. (2009). Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1. PLoS One 4, e7500.


Sauvageau, M and Sauvageau, G. (2008). Polycomb group genes: keeping stem cell activity in balance. PLoS Biol. 6, e113.

Sauvageau M, Miller M, Lemieux S, Lessard J, Hebert J, and Sauvageau G. (2008). Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia. Blood 111, 790-9.

Sauvageau G and Perreault C. (2008). Killer granzyme B linked to N-myc- and c-myc-dependent HSC survival: isn't that comyc? Cell Stem Cell 3, 579-80.

Bijl J, Krosl J, Lebert-Ghali CE, Vacher J, Mayotte N, and Sauvageau G. (2008). Evidence for Hox and E2A-PBX1 collaboration in mouse T-cell leukemia. Oncogene 27, 6356-64.


Cellot S and Sauvageau G. (2007). Zfx: at the crossroads of survival and self-renewal. Cell 129, 239-41.

Cellot S, Krosl J, Chagraoui J, Meloche S, Humphries RK, and Sauvageau G. (2007). Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells. Exp. Hematol. 35, 802-16.

Bilodeau M, Girard S, Hébert J, and Sauvageau G. (2007). A retroviral strategy that efficiently creates chromosomal deletions in mammalian cells. Nat. Methods 4, 263-268.


Chagraoui J, Niessen SL, Lessard J, Girard S, Coulombe P, Sauvageau M, Meloche S, and Sauvageau G. (2006). E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells. Genes Dev. 20, 2110-2120.

Bilodeau M and Sauvageau G. (2006). Uncovering stemness. Nat. Cell Biol. 8, 1048-1049.


Bijl J, Sauvageau M, Thompson A, and Sauvageau G. (2005). High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia. Genes Dev. 19, 224-233.


Lessard J and Sauvageau G. (2003). Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423, 255-260.

Krosl J, Beslu N, Mayotte N, Humphries RK, and Sauvageau G. (2003). The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential. Immunity 18, 561-571.

Krosl J, Austin P, Beslu N, Kroon E, Humphries RK, and Sauvageau G. (2003). In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat. Med. 9, 1428-1432.


Antonchuk J, Sauvageau G, and Humphries RK. (2002). HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 109, 39-45.


Thorsteinsdottir U, Kroon E, Jerome L, Blasi F, and Sauvageau G. (2001). Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia. Mol. Cell. Biol. 21, 224-234.

Kroon E, Thorsteinsdottir U, Mayotte N, Nakamura T, Sauvageau G. (2001). NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice. EMBO J. 20, 350-361.


IRIC Great Challenges Against Cancer

The IRIC Great Challenges are proud to be partnering with the Grand Prix Cycliste de Montréal

On September 14, ride the official circuit to help in the fight against cancer.

IRIC - Scientific Lecture
June 5th 2014 - 12pm
RNA-mediated epigenetic inheritance in the ciliate Oxytricha

IRIC - Scientific Lecture
May 26th 2014 - 4pm
A systems biology approach to bone marrow failure

IRIC - Scientific Lecture
May 13th 2014 - 7pm
Development of Proteomic Clinical Assays Based on High-Resolution / Accurate Mass Spectrometry