Selected Publications


2014

Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hébert J, Sauvageau G, Lemieux S, Lécuyer E, Veiga DF, Hoang T (2014). SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells. PLoS Genet. DOI: 10.1371/journal.pgen.1004768

Lavallé VP, Gendron P, Lemieux S, D'Angelo G, Hébert J, Sauvageau G. (2014). EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations. Blood. DOI: 10.1182/blood-2014-07-591529

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJHF, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove N, Humphries RK, Eaves C, Cohen S, Marinier A, Zandstra PW, Sauvageau G. (2014). Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science 345(6203):1509-12.

Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G. (2014). UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Blood. 124(15):2362-9. DOI: 10.1182/blood-2014-01-548651

Buscarlet M, Krasteva V, Ho LN, Simon C, Hebert J, Wilhelm B, Crabtree GR, Sauvageau G, Thibault P, Lessard JA (2014). Essential Role of Brg, the Atpase Subunit of Baf Chromatin Remodeling Complexes, in Leukemia Maintenance. Blood. 123(11):1720-8.

Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G. (2014). Identification of small molecules that support human leukemia stem cell activity ex vivo. Nature Methods. 11(4):436-42. doi:10.1038/nmeth.2847

Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang RG, Krosl J, Yung E, Kirschner J, Rosten P, Underhill TM, Jin J, Hebert J, Sauvageau G, Humphries RK, Rossi FM (2014). The Methyltransferase G9a Regulates Hoxa9-Dependent Transcription in AML. Genes Dev. 28(4):317-27.

2013

Macrae T, Sargeant T, Lemieux S, Hébert J, Deneault E, Sauvageau G. (2013). RNA-Seq Reveals Spliceosome and Proteasome Genes as Most Consistent Transcripts in Human Cancer Cells. PLoS ONE 2013-01-01;8(9):e72884.

Cellot S, Hope KJ, Chagraoui J, Sauvageau M, Deneault E, Macrae T, Mayotte N, Wilhelm BT, Landry JR, Ting SB, Krosl J, Humphries K, Thompson A, Sauvageau G. (2013). RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity. Blood. doi: 10.1182/blood-2013-04-496281

Deneault E, Wilhelm BT, Bergeron A, Barabé F, Sauvageau G. (2013). Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity. Exp Hematol. Jan 19. [Epub ahead of print]

2012

Simon C, Chagraoui J, Krosl J, Sauvageau G. (2012). A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes Dev. 26, 651-656.

2011

Ting SB, Deneault E, Hope K, Cellot S, Chagraoui J, Mayotte N, Dorn JF, Laverdure JP, Harvey M, Hawkins ED, Russell SM, Maddox PS, Iscove NN, Sauvageau G.(2011). Asymmetrical segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2. Blood 119,2510-2522.

Bisaillon R, Wilhelm BT, Krosl J, Sauvageau G. (2011). C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein. Blood 118, 4682-4689.

Chagraoui J, Hebert J, Girard S, Sauvageau G. (2011). An anticlastogenic function for the Polycomb Group gene Bmi1. PNAS 108(13):5284-9.

Wilhelm BT, Briau M, Austin P, Faubert A, Boucher G, Chagnon P, Hope K, Girard S, Mayotte N, Landry JR, Hebert J, Sauvageau G. (2011). RNA-seq Analysis of Two Closely Related Leukemia clones that Differ in their Self-Renewal Capacity. Blood 117,27-38.

2010

Fortier S, Bilodeau M, MacRae T, Laverdure JP, Azcoitia V, Girard S, Chagraoui J, Ringuette N, Hébert J, Krosl J, Mayotte N, Sauvageau G. (2010). Genome-Wide Interrogation of Mammalian Stem Cell Fate Determinants by Nested Chromosome Deletions. PLoS Genetics 6(12): e1001241.

Sauvageau M and Sauvageau G. (2010). Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer. Cell Stem Cell 7, 299-313.

Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, Sauvageau G. (2010). An RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity. Cell Stem Cell 7, 101-113.

Krosl J, Mamo A, Chagraoui J, Wilhelm BT, Girard S, Louis I, Lessard J, Perreault C, Sauvageau G. (2010). A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell population. Blood 116, 1678-1684.

2009

Deneault E, Cellot S, Faubert A, Laverdure JP, Frechette M, Chagraoui J, Mayotte N, Sauvageau M, Ting SB, Sauvageau G. (2009). A Functional Screen to Identify Novel Effectors of Hematopoietic Stem Cell Activity. Cell, 137, 369-379.

Bilodeau M, MacRae T, Gaboury L, Laverdure JP, Hardy MP, Mayotte N, Paradis V, Harton S, Perreault C, Sauvageau G. (2009). Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1. PLoS One 4, e7500.

2008

Sauvageau M, Sauvageau G. (2008). Polycomb group genes: keeping stem cell activity in balance. PLoS Biol. 6, e113.

Sauvageau M, Miller M, Lemieux S, Lessard J, Hebert J, Sauvageau G. (2008). Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia. Blood 111, 790-9.

Sauvageau G, Perreault C. (2008). Killer granzyme B linked to N-myc- and c-myc-dependent HSC survival: isn't that comyc? Cell Stem Cell 3, 579-80.

Bijl J, Krosl J, Lebert-Ghali CE, Vacher J, Mayotte N, and Sauvageau G. (2008). Evidence for Hox and E2A-PBX1 collaboration in mouse T-cell leukemia. Oncogene 27, 6356-64.

2007

Cellot S and Sauvageau G. (2007). Zfx: at the crossroads of survival and self-renewal. Cell 129, 239-41.

Cellot S, Krosl J, Chagraoui J, Meloche S, Humphries RK, and Sauvageau G. (2007). Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells. Exp. Hematol. 35, 802-16.

Bilodeau M, Girard S, Hébert J, Sauvageau G. (2007). A retroviral strategy that efficiently creates chromosomal deletions in mammalian cells. Nat. Methods 4, 263-268.

2006

Chagraoui J, Niessen SL, Lessard J, Girard S, Coulombe P, Sauvageau M, Meloche S, Sauvageau G. (2006). E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells. Genes Dev. 20, 2110-2120.

Bilodeau M and Sauvageau G. (2006). Uncovering stemness. Nat. Cell Biol. 8, 1048-1049.

2005

Bijl J, Sauvageau M, Thompson A, Sauvageau G. (2005). High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia. Genes Dev. 19, 224-233.

2003

Lessard J, Sauvageau G. (2003). Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423, 255-260.

Krosl J, Beslu N, Mayotte N, Humphries RK, Sauvageau G. (2003). The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential. Immunity 18, 561-571.

Krosl J, Austin P, Beslu N, Kroon E, Humphries RK, Sauvageau G. (2003). In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat. Med. 9, 1428-1432.

2002

Antonchuk J, Sauvageau G, Humphries RK. (2002). HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 109, 39-45.

2001

Thorsteinsdottir U, Kroon E, Jerome L, Blasi F, Sauvageau G. (2001). Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia. Mol. Cell. Biol. 21, 224-234.

Kroon E, Thorsteinsdottir U, Mayotte N, Nakamura T, Sauvageau G. (2001). NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice. EMBO J. 20, 350-361.

News



December 19, 2014

New publication for Dr. Sauvageau and his collegues from IRIC

SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells

October 19, 2014

Dr. Guy Sauvageau and his team have been nominated as «Personality of the Week» by the daily La Presse

It is for the discovery of a new molecule, the first of its kind, which allows for the multiplication of stem cells in a unit of cord blood. Umbilical cord stem cells are used for transplants aimed at curing a number of blood-related diseases, including leukemia, myeloma and lymphoma.