- Scientific Director and CEO, Institute for Research in Immunology and Cancer (IRIC) - Principal Investigator, IRIC AWARDS & HONORS- Professor, Department of Medicine, Université de Montréal - Adjunct Professor, Department of Experimental Medicine, McGill University - Hematologist, Bone Marrow Transplant Centre, Maisonneuve-Rosemont Hospital - Scientific Director, Quebec Leukemia Cell Bank - Canada Research Chair in Molecular Genetics of Stem Cells 2004 - ... - Stohlman Scholar, The Leukemia & Lymphoma Society 2007 - McCulloch & Till Award, International Society for Experimental Hematology 2006 - Scholar, The Leukemia & Lymphoma Society 2002 - 2007 RESEARCH ACHIEVEMENTS I am a researcher and clinical practinioner, specializing in the transplantation of bone marrow-derived stem cells and in the study of the molecular mechanism involved in their self-renewal. A disruption of the production mechanism of these cells is responsible for a large variety of human illnesses and clinical problems. For example, uncontrolled growth of bone marrow stem cells causes leukemia; our current inability to stimulate their renewal is a serious impediment to successful human bone marrow transplants. Over the last fifteen years, our lab has worked towards understanding the mechanisms controlling production of hematopoietic stem cells. Our research identified HOX and Polycomb Group genes as being instrumental in regulating the self-renewal of normal and leukemic stem cells. More recently, we have developed an in vitro-in vivo screen which allowed us to identify several new regulators of HSC self-renewal division. We also generated recombinant HOX proteins that lead to the expansion of the hematopoietic stem cells. Clinical phases I an II will soon begin, with umbilical cord blood as a source of essential stem cells for patients requiring a transplant when there is no compatible donor. The basic research carried out in our lab will hopefully translate into better patient care. |
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