HSC Self-Renewal Networks

Mapping and dissecting human HSC self-renewal networks

Towards an ideal cord blood graft

Chemo-genomic tools to produce the ideal cord blood graft

Acute Myeloid Leukemia

Understanding AML with chemo-genomics

Genome Wide Annotation of Stem Cell Determinants

Interrogation of mammalian stem cells fate regulators

  • HSC Self-Renewal Networks

  • Towards an ideal cord blood graft

  • Acute Myeloid Leukemia

  • Genome Wide Annotation of Stem Cell Determinants

Sauvageau Lab

Based in Montréal, Canada, the Sauvageau Lab is part of the Institute for Research in Immunology and Cancer (IRIC), at Université de Montréal.

Our research program aims to decipher the basic mechanisms that regulate the activity of normal and leukemia stem cells with the ultimate goal of identifying regulatory networks that govern specification and self-renewal of these cells.

Our approach remains to focus on the development of novel functional genomics and chemo-genomics methods that are exploited to identify uncharacterized regulators of stem cell activity.

Recent Publications

A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.
Baccelli I, Krosl J, Boucher G, et al.
Appropriate culture methods for the interrogation of primary leukemic samples were hitherto lacking and current assays for compound screening are not adapted for large-scale investigation of synergistic combinations. In this study, we report a novel approach that efficiently distills...
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New website

New website for the Leucegene project

The new Leucegene website is now online. This project aims to increase the survival rate of patients with acute myeloid leukemia by helping to determine treatment based on the genetic makeup of their leukemia cells. It is headed by Drs Guy Sauvageau (Project Leader), Josée Hébert (Co-Project Leader), Anne Marinier (Head Chemist) and Sébastien Lemieux (Head of Bioinformatics). It involves researchers from IRIC, HMR, Université Laval and McGill University.

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Recent news

December 15, 2015 - Health Canada authorizes a clinical trial for the UM171 molecule
Health Canada has officially given the green light for the first phase of clinical trials involving transplantation of cord blood cells expanded with the small molecule UM171 for the treatment of blood-related cancers. Thanks to our collaborators at IRIC and Hôpital Maisonneuve-Rosemont

October 23, 2015 - Dr. Guy Sauvageau receives the Leo-Pariseau award from ACFAS

June 12, 2016 - Dr. Vincent-Philippe Lavallée gives an interview at the 21rst congress of the European Hematology Association (EHA) in Copenhagen

ecancer.org interview.

IRIC - Université de Montréal

"Despite considerable efforts and spectacular scientific advances to fight this disease, effective treatments are lacking for most types of cancer. An ultra-modern research and training centre located in the heart of Université de Montréal, the Institute for Research in Immunology and Cancer (IRIC) was created in 2003 to shed light on the mechanisms of cancer and discover new, more effective therapies to counter this plague." (IRIC, 2014)

To learn more about the Institute, visit www.iric.ca.


November 22, 2017
The Sauvageau lab currently accepting applications for exceptional PhD students. If you are passionate about research and interested in joining our team, please submit your application toTara MacRae.

2017 IRIC Next Generation awards

The 2017 IRIC Next Generation Awards program offers students an unique opportunity to receive an undergraduate research award and to conduct an internship at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal during Summer 2017.

Application deadline Friday, February 3, 2017, 5 PM

2017 IRIC Student Recruitment Event

The 2017 IRIC Student Recruitment Event offers students interested in pursuing graduate studies in the field of cancer research a unique opportunity to participate in an international student recruitment event at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal, from June 15 to June 18, 2017.

Application deadline Monday, March 13, 2017, 5 PM

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