HSC Self-Renewal Networks

Mapping and dissecting human HSC self-renewal networks

Towards an ideal cord blood graft

Chemo-genomic tools to produce the ideal cord blood graft

Acute Myeloid Leukemia

Understanding AML with chemo-genomics

Genome Wide Annotation of Stem Cell Determinants

Interrogation of mammalian stem cells fate regulators


  • HSC Self-Renewal Networks


  • Towards an ideal cord blood graft


  • Acute Myeloid Leukemia


  • Genome Wide Annotation of Stem Cell Determinants


Sauvageau Lab


Based in Montréal, Canada, the Sauvageau Lab is part of the Institute for Research in Immunology and Cancer (IRIC), at Université de Montréal.

Our research program aims to decipher the basic mechanisms that regulate the activity of normal and leukemia stem cells with the ultimate goal of identifying regulatory networks that govern specification and self-renewal of these cells.

Our approach remains to focus on the development of novel functional genomics and chemo-genomics methods that are exploited to identify uncharacterized regulators of stem cell activity.


Recent Publications


The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias
Lavallée VP, Baccelli I, Krosl J, et al.
Using next-generation sequencing of primary acute myeloid leukemia (AML) specimens, we identified to our knowledge the first unifying genetic network common to the two subgroups of KMT2A (MLL)-rearranged leukemia...
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New website

New website for the Leucegene project

The new Leucegene website is now online. This project aims to increase the survival rate of patients with acute myeloid leukemia by helping to determine treatment based on the genetic makeup of their leukemia cells. It is headed by Drs Guy Sauvageau (Project Leader), Josée Hébert (Co-Project Leader), Anne Marinier (Head Chemist) and Sébastien Lemieux (Head of Bioinformatics). It involves researchers from IRIC, HMR, Université Laval and McGill University.

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Recent news



December 15, 2015 - Health Canada authorizes a clinical trial for the UM171 molecule
Health Canada has officially given the green light for the first phase of clinical trials involving transplantation of cord blood cells expanded with the small molecule UM171 for the treatment of blood-related cancers. Thanks to our collaborators at IRIC and Hôpital Maisonneuve-Rosemont

October 23, 2015 - Dr. Guy Sauvageau receives the Leo-Pariseau award from ACFAS

IRIC - Université de Montréal


"Despite considerable efforts and spectacular scientific advances to fight this disease, effective treatments are lacking for most types of cancer. An ultra-modern research and training centre located in the heart of Université de Montréal, the Institute for Research in Immunology and Cancer (IRIC) was created in 2003 to shed light on the mechanisms of cancer and discover new, more effective therapies to counter this plague." (IRIC, 2014)

To learn more about the Institute, visit www.iric.ca.

News



February 2, 2016

2016 IRIC Next Generation awards

The 2016 IRIC Next Generation Awards program offers students an unique opportunity to receive an undergraduate research award and to conduct an internship at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal during Summer 2016.

Application deadline Friday, February 5, 2016, 5 PM

2016 IRIC Student Recruitment Event

The 2016 IRIC Student Recruitment Event offers students interested in pursuing graduate studies in the field of cancer research a unique opportunity to participate in an international student recruitment event at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal, from June 16 to June 19, 2016.

Application deadline Monday, March 14, 2016, 5 PM


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